Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8
USERS' SCORE
Moderately Good
Based on 43 Reviews
7.9
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Glutathione (Reduced Form)
500 mg
**
Milk Thistle Extract (Silybum marianum) (Fruit/Seeds) (Standardized to 80 mg Silymarin Flavonoids - equivalent 80%)
100 mg
**
Alpha Lipoic Acid
50 mg
**
Top Medical Research Studies
9
We investigated how silybin, a unique flavonoid found in certain plants, impacts autoimmune disorders, specifically using a model for multiple sclerosis called experimental autoimmune encephalomyelitis (EAE).
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
Read More
9
Silibinin shows immunosuppressive effects
We explored the effects of silibinin, derived from silymarin (Silybum marianum), on autoimmune disorders, particularly multiple sclerosis. In a study using an animal model, we observed that silibinin notably reduced signs of spinal cord damage and inflammation, suggesting its potential immunosuppressive effects.
Additionally, silibinin was found to modulate cytokine production by lowering pro-inflammatory Th1 cytokines while increasing anti-inflammatory Th2 cytokines. This indicates that silibinin could be both immunosuppressive and beneficial for managing autoimmune responses, though further research is necessary to confirm its effectiveness in clinical settings.
Additionally, silibinin was found to modulate cytokine production by lowering pro-inflammatory Th1 cytokines while increasing anti-inflammatory Th2 cytokines. This indicates that silibinin could be both immunosuppressive and beneficial for managing autoimmune responses, though further research is necessary to confirm its effectiveness in clinical settings.
Read More
9
Silibinin shows promise in autoimmunity
We explored how silibinin, a compound derived from milk thistle, may influence autoimmune disorders like rheumatoid arthritis (RA).
Through our study, which included both healthy individuals and RA patients, we found that silibinin enhances the expression of estrogen receptor beta (ERβ) and promotes apoptosis in T lymphocytes, leading to reduced inflammation.
It also acts on microRNA-155, which is linked to RA's progression. These findings suggest that silibinin holds promise as both a treatment option and a dietary supplement for managing autoimmune diseases.
Through our study, which included both healthy individuals and RA patients, we found that silibinin enhances the expression of estrogen receptor beta (ERβ) and promotes apoptosis in T lymphocytes, leading to reduced inflammation.
It also acts on microRNA-155, which is linked to RA's progression. These findings suggest that silibinin holds promise as both a treatment option and a dietary supplement for managing autoimmune diseases.
Read More
Most Useful Reviews
8
Restored health
48 people found this helpful
I ordered this product to prevent worsening due to the coronavirus. I read it might help with complications, and it arrived in just three days. Thanks to glutathione, my health returned to normal within a week. My skin also looks good. It appears to be beneficial for skin brightening, and I’m keen to keep taking it.
Read More
7.5
Positive treatment response
32 people found this helpful
Glutathione was recommended by my immunologist as part of my treatment for an autoimmune disorder. I took the first course a year ago and have just purchased it again. I’ve noticed a positive impact on my condition despite initial doubts about the cost and conflicting online information regarding glutathione absorption.
Read More
7.5
Reduces oxidative stress
24 people found this helpful
It works perfectly! As a doctor, I understand the benefits of glutathione, alpha-lipoic acid, and milk thistle. This formula is exceptional and not found in other brands. It reduces oxidative stress, supports skin health, lowers cell damage risk from fatty liver disease, improves insulin resistance, and has shown promise in research for type 2 diabetes. It aids in weight loss and lessens symptoms of Parkinson’s disease and some autoimmune disorders while bolstering immune responses.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8
- All Researches
9
We investigated how silybin, a unique flavonoid found in certain plants, impacts autoimmune disorders, specifically using a model for multiple sclerosis called experimental autoimmune encephalomyelitis (EAE).
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
Read More
9
Silibinin shows promise in autoimmunity
We explored how silibinin, a compound derived from milk thistle, may influence autoimmune disorders like rheumatoid arthritis (RA).
Through our study, which included both healthy individuals and RA patients, we found that silibinin enhances the expression of estrogen receptor beta (ERβ) and promotes apoptosis in T lymphocytes, leading to reduced inflammation.
It also acts on microRNA-155, which is linked to RA's progression. These findings suggest that silibinin holds promise as both a treatment option and a dietary supplement for managing autoimmune diseases.
Through our study, which included both healthy individuals and RA patients, we found that silibinin enhances the expression of estrogen receptor beta (ERβ) and promotes apoptosis in T lymphocytes, leading to reduced inflammation.
It also acts on microRNA-155, which is linked to RA's progression. These findings suggest that silibinin holds promise as both a treatment option and a dietary supplement for managing autoimmune diseases.
Read More
9
We analyzed how Silymarin affects the Pdx1 gene expression and insulin production in a model of diabetes following partial pancreatic removal. With 72 rats divided into groups, those treated with Silymarin showed significant increases in both Pdx1 and insulin levels compared to untreated rats.
Notably, the treatment led to a remarkable boost in β-cell proliferation, enhancing insulin secretion and reducing blood sugar levels. These findings highlight Silymarin's potential to support the recovery of insulin-producing cells in diabetic conditions.
Notably, the treatment led to a remarkable boost in β-cell proliferation, enhancing insulin secretion and reducing blood sugar levels. These findings highlight Silymarin's potential to support the recovery of insulin-producing cells in diabetic conditions.
Read More
9
Silibinin shows immunosuppressive effects
We explored the effects of silibinin, derived from silymarin (Silybum marianum), on autoimmune disorders, particularly multiple sclerosis. In a study using an animal model, we observed that silibinin notably reduced signs of spinal cord damage and inflammation, suggesting its potential immunosuppressive effects.
Additionally, silibinin was found to modulate cytokine production by lowering pro-inflammatory Th1 cytokines while increasing anti-inflammatory Th2 cytokines. This indicates that silibinin could be both immunosuppressive and beneficial for managing autoimmune responses, though further research is necessary to confirm its effectiveness in clinical settings.
Additionally, silibinin was found to modulate cytokine production by lowering pro-inflammatory Th1 cytokines while increasing anti-inflammatory Th2 cytokines. This indicates that silibinin could be both immunosuppressive and beneficial for managing autoimmune responses, though further research is necessary to confirm its effectiveness in clinical settings.
Read More
8
Silymarin shows promise for MS
We explored the impact of silymarin, a compound from milk thistle, on the immune system in patients with multiple sclerosis (MS). By isolating Th1 cells from both newly diagnosed and treatment-receiving patients, we assessed how silymarin affected cell activity at various doses and times.
Our results indicated that silymarin effectively reduced Th1 cell proliferation and interfered with the production of key inflammatory markers. However, in patients treated with interferon-beta, there were mixed results over time, where some increases in inflammatory markers were noted. Overall, silymarin appears to hold promise as an immunomodulatory agent for MS.
Our results indicated that silymarin effectively reduced Th1 cell proliferation and interfered with the production of key inflammatory markers. However, in patients treated with interferon-beta, there were mixed results over time, where some increases in inflammatory markers were noted. Overall, silymarin appears to hold promise as an immunomodulatory agent for MS.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 43 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
8
Restored health
48 people found this helpful
I ordered this product to prevent worsening due to the coronavirus. I read it might help with complications, and it arrived in just three days. Thanks to glutathione, my health returned to normal within a week. My skin also looks good. It appears to be beneficial for skin brightening, and I’m keen to keep taking it.
Read More
7.5
Positive treatment response
32 people found this helpful
Glutathione was recommended by my immunologist as part of my treatment for an autoimmune disorder. I took the first course a year ago and have just purchased it again. I’ve noticed a positive impact on my condition despite initial doubts about the cost and conflicting online information regarding glutathione absorption.
Read More
7.5
Reduces oxidative stress
24 people found this helpful
It works perfectly! As a doctor, I understand the benefits of glutathione, alpha-lipoic acid, and milk thistle. This formula is exceptional and not found in other brands. It reduces oxidative stress, supports skin health, lowers cell damage risk from fatty liver disease, improves insulin resistance, and has shown promise in research for type 2 diabetes. It aids in weight loss and lessens symptoms of Parkinson’s disease and some autoimmune disorders while bolstering immune responses.
Read More
7.5
Positive well-being changes
11 people found this helpful
I ordered glutathione for my husband as part of a regimen based on the autoimmune protocol, having observed benefits through trial. After three weeks, we've seen positive changes in his well-being. The quality of this product is commendable, and his joint inflammation has noticeably decreased, while his skin has cleared up. Although autoimmune disease isn't curable, it can enter remission.
Read More
9
Effective for fatigue
10 people found this helpful
Fatigue and dull skin have disappeared. Glutathione is pricey, so I held off initially. To tackle ageing, I finally tried this supplement, wishing I had done so sooner. It's effective for skin texture and reduces sluggishness, even before my period. I take it every two days at night with liposomal vitamin C. I highly recommend it!
Read More
Frequently Asked Questions
8
Restored health
48 people found this helpful
I ordered this product to prevent worsening due to the coronavirus. I read it might help with complications, and it arrived in just three days. Thanks to glutathione, my health returned to normal within a week. My skin also looks good. It appears to be beneficial for skin brightening, and I’m keen to keep taking it.
7.5
Positive well-being changes
11 people found this helpful
I ordered glutathione for my husband as part of a regimen based on the autoimmune protocol, having observed benefits through trial. After three weeks, we've seen positive changes in his well-being. The quality of this product is commendable, and his joint inflammation has noticeably decreased, while his skin has cleared up. Although autoimmune disease isn't curable, it can enter remission.
6
Clearer skin
5 people found this helpful
This is my third order of these pills. The quantity is sufficient for two months. I take one pill daily on an empty stomach, then wait a while before eating. From day one, I recognised the benefits – my skin looked clearer, and staying well-hydrated improved the results further. I trust this company’s products due to their excellent quality and good pricing.
9
Brightened complexion
1 people found this helpful
Excellent! I ordered it to brighten my face. I completed the course and was pleased with the results, so I ordered more. The pigmentation has diminished, and my complexion is now more even. I'm really glad.
9
Rejuvenates stamina
1 people found this helpful
As someone with low stamina, I found that glutathione pills significantly alleviate chronic fatigue. After running out and being tired for two weeks, I resumed taking it and my stamina has normalised. Though everyone's body is different, I'd recommend this to anyone dealing with low stamina.
8
Boosts stamina quickly
1 people found this helpful
Glutathione is fantastic! As a powerful antioxidant, it combats liver toxicity, which I hoped would help my reduced stamina after a recent illness. After only two days, I felt a dramatic improvement. My overall tiredness and sleepiness disappeared, and I found it easier to increase my activity level. It's well-packaged and easy to swallow.
7.5
Less inflammation
1 people found this helpful
Helps with autoimmune disorders! I consume glutathione in courses to reduce systemic inflammation. This supplement aids in diminishing autoimmune responses and allergies of unknown origin, and I also suggest adopting a paleo diet whilst avoiding milk and gluten.
9
Effective for fatigue
10 people found this helpful
Fatigue and dull skin have disappeared. Glutathione is pricey, so I held off initially. To tackle ageing, I finally tried this supplement, wishing I had done so sooner. It's effective for skin texture and reduces sluggishness, even before my period. I take it every two days at night with liposomal vitamin C. I highly recommend it!
8
Brightening skin effect
133 people found this helpful
I'm a long-time user of glutathione and have experienced its lightening and glowing effects on my skin. I pair it with 1000 mg of Vitamin C. I recently discovered iHerb and plan to continue ordering from them in the future, as I'm very satisfied.
7.5
Reduces oxidative stress
24 people found this helpful
It works perfectly! As a doctor, I understand the benefits of glutathione, alpha-lipoic acid, and milk thistle. This formula is exceptional and not found in other brands. It reduces oxidative stress, supports skin health, lowers cell damage risk from fatty liver disease, improves insulin resistance, and has shown promise in research for type 2 diabetes. It aids in weight loss and lessens symptoms of Parkinson’s disease and some autoimmune disorders while bolstering immune responses.
9
Supports liver, reduces inflammation
104 people found this helpful
I bought this for my parents to support their liver health. For those with a history of autoimmune disorders, I recommend this product. It helps the body manage inflammation, and with a dosage of 1000mg alongside NAC and MSM, there have been significant benefits. It alleviates inflammation and supports connective tissues, so I’ll continue ordering it.
7.5
Supports liver detoxification
I purchased this for my husband to support his treatment for an autoimmune disease. It aids in liver function and detoxifies the body. This supplement is suitable for additional therapy for any autoimmune disorder, as it helps lighten the liver's burden, allowing the body more resources to combat the disease. The capsules are easy to swallow.
9
Amazing improvement
1 people found this helpful
To achieve effectiveness, ensure to take no less than two pills daily and combine them with effervescent vitamin C. The results are phenomenal; I noticed a difference from the first box personally, although results may vary from individual to individual.
7.5
Positive treatment response
32 people found this helpful
Glutathione was recommended by my immunologist as part of my treatment for an autoimmune disorder. I took the first course a year ago and have just purchased it again. I’ve noticed a positive impact on my condition despite initial doubts about the cost and conflicting online information regarding glutathione absorption.
9
We investigated how silybin, a unique flavonoid found in certain plants, impacts autoimmune disorders, specifically using a model for multiple sclerosis called experimental autoimmune encephalomyelitis (EAE).
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
8
In our research, we examined the effects of silymarin (Livergol®) on rheumatoid arthritis (RA) in a small group of 44 stable patients. After 90 days of treatment, we noticed a significant decrease in the Disease Activity Score (DAS-28), which assesses inflammation levels. Specifically, patients reported improvement in their symptoms, suggesting potential anti-inflammatory benefits from silymarin due to its antioxidant properties. However, the exact ways it works remain unclear, highlighting the need for more extensive studies with cytokine measurement to unravel its mechanisms further.
8
Silymarin shows promise for MS
We explored the impact of silymarin, a compound from milk thistle, on the immune system in patients with multiple sclerosis (MS). By isolating Th1 cells from both newly diagnosed and treatment-receiving patients, we assessed how silymarin affected cell activity at various doses and times.
Our results indicated that silymarin effectively reduced Th1 cell proliferation and interfered with the production of key inflammatory markers. However, in patients treated with interferon-beta, there were mixed results over time, where some increases in inflammatory markers were noted. Overall, silymarin appears to hold promise as an immunomodulatory agent for MS.
Our results indicated that silymarin effectively reduced Th1 cell proliferation and interfered with the production of key inflammatory markers. However, in patients treated with interferon-beta, there were mixed results over time, where some increases in inflammatory markers were noted. Overall, silymarin appears to hold promise as an immunomodulatory agent for MS.
7
Potential benefits but limited studies
We investigated how silymarin and its active ingredient, silibinin, can affect symptoms of rheumatoid arthritis (RA) and osteoarthritis (OA). Using a systematic review approach, we sifted through 437 studies, finally focusing on 21 relevant ones.
Our findings revealed that these compounds show impressive properties, such as reducing inflammation and pain and protecting joint health. However, we also noted that while the experimental evidence is promising, further clinical studies are crucial to confirm these benefits and guide effective treatment strategies.
Our findings revealed that these compounds show impressive properties, such as reducing inflammation and pain and protecting joint health. However, we also noted that while the experimental evidence is promising, further clinical studies are crucial to confirm these benefits and guide effective treatment strategies.
References
- Blum K, Elman I, Han D, Hanna C, Baron D, et al. The First Pilot Epigenetic Type Improvement of Neuropsychiatric Symptoms in a Polymorphic Dopamine D2 (-DRD2/ANKK (Taq1A)), OPRM1 (A/G), DRD3 (C/T), and MAOA (4R) Compromised Preadolescence Male with Putative PANDAS/CANS: Positive Clinical Outcome with Precision-Guided DNA Testing and Pro-Dopamine Regulation (KB220) and Antibacterial Therapies. Open J Immunol. 2024;14:60. doi:10.4236/oji.2024.143006
- Ghahfarrokhi SH, Heidari-Soureshjani S, Sherwin CMT, Azadegan-Dehkordi Z. Efficacy and Mechanisms of , Silymarin, and Silibinin on Rheumatoid Arthritis and Osteoarthritis Symptoms: A Systematic Review. Curr Rheumatol Rev. 2024;20:414. doi:10.2174/0115733971266397231122080247
- Yang HL, Shi XW. Silybin Alleviates Experimental Autoimmune Encephalomyelitis by Suppressing Dendritic Cell Activation and Th17 Cell Differentiation. Front Neurol. 2021;12:659678. doi:10.3389/fneur.2021.659678
- Ghiasian M, Nafisi H, Ranjbar A, Mohammadi Y, Ataei S. Antioxidative effects of silymarin on the reduction of liver complications of fingolimod in patients with relapsing-remitting multiple sclerosis: A clinical trial study. J Biochem Mol Toxicol. 2021;35:e22800. doi:10.1002/jbt.22800
- Navabi F, Shaygannejad V, Abbasirad F, Vaez E, Hosseininasab F, et al. Immunoregulatory Effects of Silymarin on Proliferation and Activation of Th1 Cells Isolated from Newly Diagnosed and IFN-ß-Treated MS Patients. Inflammation. 2019;42:54. doi:10.1007/s10753-018-0872-x
- Dupuis ML, Conti F, Maselli A, Pagano MT, Ruggieri A, et al. The Natural Agonist of Estrogen Receptor β Silibinin Plays an Immunosuppressive Role Representing a Potential Therapeutic Tool in Rheumatoid Arthritis. Front Immunol. 2018;9:1903. doi:10.3389/fimmu.2018.01903
- Shavandi M, Moini A, Shakiba Y, Mashkorinia A, Dehghani M, et al. Silymarin (Livergol®) Decreases Disease Activity Score in Patients with Rheumatoid Arthritis: A Non-randomized Single-arm Clinical Trial. Iran J Allergy Asthma Immunol. 2017;16:99.
- Soto C, Raya L, Juárez J, Pérez J, González I. Effect of Silymarin in Pdx-1 expression and the proliferation of pancreatic β-cells in a pancreatectomy model. Phytomedicine. 2014;21:233. doi:10.1016/j.phymed.2013.09.008
- Gharagozloo M, Javid EN, Rezaei A, Mousavizadeh K. Silymarin inhibits cell cycle progression and mTOR activity in activated human T cells: therapeutic implications for autoimmune diseases. Basic Clin Pharmacol Toxicol. 2013;112:251. doi:10.1111/bcpt.12032
- Min K, Yoon WK, Kim SK, Kim BH. Immunosuppressive effect of silibinin in experimental autoimmune encephalomyelitis. Arch Pharm Res. 2007;30:1265.
